Novartis Ag

Anthony Casarez

Robert Lowell Simmons

Folkert Reck

Xiaodong Lin

Qingming Zhu

Mika Lindvall

Heinz Ernst Moser

Aregahegn Yifru

Meiliana Tjandra

Glenn McEnroe

Guido Koch

Virender Singh Aulakh

Markus Furegati

Flavio Ossola

Michael Mutz

Zaixing Li

Andreas Fisch

Bernd Ulrich Riebesehl

Vijay Sethuraman

Marc Schoenhentz

Eric Aubin

Glenn Mcenroe

The invention provides new solid forms, salts and polymorphs of 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to herein as Compound X), pharmaceutical compositions containing them, and processes for their manufacture and use in therapy.

Salts and solid forms of a monobactam antibiotic

This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains. 

Beta-lactamase inhibitors

This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

Monobactam organic compounds for the treatment of bacterial infections

This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.

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San Francisco, CA, United States of America

Anthony Casarez