Waters Technologies Corporation

Anthony C Jeannotte

Mark Basile

John Leason

Keith Fadgen

Anthony C Gilby

Dennis DellaRovere

Christopher C Benevides

Colin Fredette

Senthil Bala

Michael Lavallee

Daniel Gillund

Aditya Shankar Prasad

Saksham Saxena

Theodore A Dourdeville

Charles T Murphy

Theordore A Dourdeville

John A Leason

The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

Systems and methods for refractive index detection

A detector for use in liquid chromatography is provided. The detector includes a light delivery system comprising a light source that emits one or more spectral lines of light of a light spectrum. The detector has an entrance slit configured to receive the one or more spectral lines of light and a wavelength selection module comprising a digital micro-mirror device. The digital micro-mirror device is configured to redirect the one or more spectral lines of light to a flow cell. The flow cell is optically connected to the wavelength selection module.

DMD based UV absorption detector for liquid chromatography

A flow cell for differential refractive index detection. The flow cell includes a transparent body that extends from a first end to a second end along a longitudinal axis. The transparent body defines a sample prism chamber and reference prism chamber. The sample prism chamber is configured to allow fluid flow between the first and second ends of the transparent body along the longitudinal axis. The reference prism chamber is configured to receive a reference fluid. The sample and reference prism chambers each include a grating comprising a plurality of grooves extending along the longitudinal axis in the direction of fluid flow.

Flow cells for differential refractive index detection

A fluidic coupler assembly () for use in a light-guided flow cell comprises a coupler body () having a sealing face (), a tubular insert such as an optical fiber () passing through a through bore () of the coupler body and through a ferrule () located adjacent the sealing face of the coupler body. A backing plug () holds the ferrule in position within the coupler body.

Fluidic coupler assembly with conical ferrule

A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Liquid-chromatography conduit assemblies having high-pressure seals

The present invention is directed to devices and methods for performing photoreactions of photo-reacting compounds in solution. The invention features a vessel defining a chamber and a light source. The chamber has a chamber volume, a first window, an inlet and an outlet. The inlet is placed in fluid communication with a source of photo-reacting compounds in solution. The first window is transparent to light transmission and is placed in optical communication with a light source to receive photons. The chamber receives a solution of one or more photo-reactive compounds over time to define a dwell time. The device further includes a light source, in optical communication with the first window, for emitting photons which photons are received by the first window and transmitted into the chamber.

Apparatus and methods for performing photoreactions and analytical methods and devices to detect photo-reacting compounds

The present invention relates to a device having an optical fiber coupled to a high pressure containment vessel and a method for making the same. The high pressure containment vessel can be an optical fiber based flow cell for a chromatography system.

Methods of making and using an apparatus and devices for placing light and sample in photo-emitting or absorbing device

The present invention relates to apparatus and devices () for placing light with samples for analysis and method of making and using such apparatus and device.

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Foxborough, MA, United States of America

Anthony C Jeannotte