Merck + Co., Inc.

Anthony B Jones

Arthur A Patchett

Richard L Tolman

Thomas F Walsh

Kun Liu

Donald W Graham

Soumya P Sahoo

Harold B Wood

Alan D Adams

Derek J Von Langen

Richard B Toupence

Kenneth J Fitch

Conrad Santini

Gregory D Berger

Joel Peter Berger

David E Moller

Mark D Leibowitz

Bei B Zhang

The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.

Benzisoxazole-derived antidiabetic compounds

Compounds of formula I: ##STR1## as well as tautomers, pharmaceutically acceptable salts, hydrates, prodrugs and reduced forms are disclosed. The compounds are useful for the treatment and prevention of diabetes mellitus, and in particular, for the treatment or prevention of hyperglycemia in diabetic patients.

Antidiabetic agents

Compounds of the formula: ##STR1## where R is hydrogen, C.sub.1 -C.sub.10 alkylcarbonyl, or C.sub.1 -C.sub.10 alkyl which can be substituted by amino or cyano, R.sup.1 and R.sup.2 are independently hydrogen, hydroxyl or amino, and the pharmaceutically aceptable salts and esters thereof. Pharmaceutical compositions and methods of their use are also provided for.

10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof

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Scotch Plains, NJ, United States of America

Anthony B Jones