University of Florida Research Foundation, Incorporated

Sharklet Technologies, Inc.

Insight Innovations, LLC

Anthony B Brennan

Ronald Howard Baney

James Frederick Schumacher

Mark M Spiecker

Michael P Zamora

Adam Walter Feinberg

Thomas Gregory Estes

Ryan Eugene Stoneberg

Walter Scott Thielman

Shravanthi T Reddy

Chelsea Marie Magin

Leslie H Wilson

Joseph W Bagan

Kenneth K Chung

Christopher D Batich

Kenneth Boone Wagener

Rhea Marie May

Michael Ryan Mettetal

Michelle L Carman

Rodrigo L Orefice

Ethan Eugene Mann

Charles Alan Seegert

Gregory Scott Schultz

Kirk S Schanze

Brian Joseph Cuevas

Michelle Carman Turnage

Bradley Jay Willenberg

Kevin H Cuevas

David A Jenkins

Bruce I Carroll

Wissam El-Ratal

James Hubner

Liu He

Yingsheng Wang

Yibling Shen

Yun Mi Kim

Peter Ifju

Dylan Burton Neale

Clayton C Bohn, Jr

Brian M Hatcher

Christopher James Long

Jiun-Jeng Chen

Canan Kizilkaya

Laura M Villada

Mark Mccullough Spiecker

Clayton C Bohn

Walter Scott Thielmann

Clayton Bohn

Disclosed herein is a method comprising transporting a conduit and a template through a guide tube; the template being disposed on an outer surface of the conduit between the conduit and the guide tube; and transferring a texture from the template to the conduit as the conduit and the template are transported through the guide tube. Disclosed herein too is an apparatus comprising a guide tube; the guide tube being operative to facilitate a transfer of a pattern from a template to a conduit; a first feed spool and a first take-up spool for feeding the conduit through the guide tube and for taking up the conduit after it has travelled through the guide tube respectively; and a second feed spool and a second take-up spool for feeding the template through the guide tube and for taking up the template after it has travelled through the guide tube respectively.

Method of manufacturing catheter for antimicrobial control

Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

Bilayered devices for enhanced healing

An article has a curved surface. Disposed upon the curved surface is a plurality of patterns. Each pattern is defined by a plurality of spaced apart features attached to or projected into the curved surface. The plurality of features each have at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent features is about 1 nanometer and about 1 millimeter in at least a portion of the curved surface. The plurality of spaced apart features are represented by a periodic function.

Method of patterning a surface and articles comprising the same

An article includes a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface. The first plurality of spaced features are arranged in a plurality of groupings. The groupings of features comprise repeat units, where the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features.

Patterns for flow control and bioadhesion control

Catheter for antimicrobial control and method of manufacturing thereof

Disclosed herein a composition comprising a urethane of the FIG.; where hydroxyl or amine linkages on the urethane of the FIG.are functionalized with molecules that contain fluorine atoms, phosphorus atoms, sulfur atoms, unsaturated carboxylic acids, derivatives of unsaturated carboxylic acids, or combinations thereof. Disclosed herein too is a composition comprising a urethane of the FIG.; where hydroxyl or amine linkages of the urethane of the FIG.are functionalized with molecules that contain fluorine atoms, phosphorus atoms, sulfur atoms, unsaturated carboxylic acids, derivatives of unsaturated carboxylic acids, or combinations thereof; and a polymeric resin.

Polyurethanes, articles comprising the same and methods of manufacture thereof

Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Micropatterned intraocular implant

Disclosed herein is an article comprising a substrate; a polymer disposed upon the substrate; the polymer having a number average molecular weight of about 2,000 to about 5,000 grams per mole; where each polymer is separated from a neighboring polymer by an average distance of 2.5 Angstroms to 5,000 Angstroms. Disclosed herein is a method comprising disposing upon a substrate a polymer; the polymer having a number average molecular weight of 2,000 to about 5,000 grams per mole.

Antifouling surfaces, methods of manufacture thereof and articles comprising the same

Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

Surface topographies for non-toxic bioadhesion control

An article has a surface topography for resisting bioadhesion of organisms and includes a base article having a surface. A composition of the surface includes a polymer. The surface has a topography comprising a pattern defined by a plurality of spaced apart features attached to or projected into the base article. The plurality of features each have at least one microscale dimension and at least one neighboring feature having a substantially different geometry. An average feature spacing between adjacent ones of the features is between 10 &#x3bc;m and 100 &#x3bc;m in at least a portion of the surface. The surface topography can be numerically represented using at least one sinusoidal function. In one embodiment, the surface can comprise a coating layer disposed on the base article.

A bioactive sol-gel solution includes a biocompatible polymer, a gelable inorganic base material, and at least one calcium and phosphorous molecular species. The base material can be an alkoxide, such as TEOS. The polymer acts as a viscosity modifier to the sol or gel, increases the viscosity range over which fibers can be sprayed or spun, and broadens the time period over which fibers can be sprayed or spun. A bioactive glass composite can be formed from the bioactive sol-gel solution, including a fibrous form. Fibers can serve as a scaffold for cell growth and in the repair of hard or soft tissue defects.

Sol-gel derived bioactive glass polymer composite

A method of destroying target microorganisms comprises the step of contacting at least one target microorganism with at least one low molecular weight silanol end group containing molecule. The silanol containing molecule is selected from silanols (RRRSiOH), siloxanediols HO(RRSiO)nH or siloxanols HO(RRSiO)nSiRRR, where R, Rand Rare selected from 1 to 4 carbon alkyl or fluoroalkyl moieties, or vinyl, or aryl groups and n is &#x3c;6 . The silanol end group containing molecule can be triethylsilanol, diphenylmethylsilanol, t-butyldimethylsilanol, n-butyldimethylsilanol, n-propyldimethylsilanol, ethyldimethylsilanol, vinylphenylmethylsilanol, phenyldimethylsilanol, 3,3,3 trifluoro propyldimethylsilanol, benzyldimethylsilanol and phenethyldimethylsilanol, or mixtures thereof. A composition of matter includes a silanol end group containing molecule according to the invention blended with a polymer or dissolved in aqueous solution along with an ether-based cosolvent.

Biocides based on silanol terminated silanes and siloxanes

Growing community of inventors

Gainesville, FL, United States of America

Anthony B Brennan