Enviroderm Pharmaceuticals, Inc.

United Catalysts Inc.

Anthony A Schulz

Gary W Beall

Thomas W Powell, Jr

David J Buddrus

Skin irritation, such as diaper rash, appearing when the skin is allowed to remain in contact with proteolytic enzymes found in feces is prevented by inactivating the fecal proteolytic enzymes by contact with organophilic clays. The organophilic clays are applied to the skin in areas likely to come into contact with feces or to garments such as diapers. A composition suitable for practicing the method of the invention comprises an amount of an organophilic clay effective to inactivate irritating fecal proteolytic enzymes dispersed in a pharmaceutically acceptable non-toxic dermatological vehicle. A fabric incorporating organophilic clay, preferably dispersed in a matrix of a superabsorbent polymer is useful for preparing diapers for infants that can help to prevent skin irritation by fecal enzymes.

Composition for prevention skin irritation caused by fecal enzymes

Fabric or garment containing fecal enzyme inhibitor

Method of preventing skin irritation caused by fecal enzymes

A lotion capable of protecting the skin from the effects of exposure to irritants and allergens, particularly those produced by toxic plants such as poison ivy, has the following composition, wherein the proportions are by weight:

Skin allergen and irritant barrier lotion

An allergen absorbent and blocking aerosol composition for topical application to the skin comprises a highly activated organophilic clay of the smectite type, ion exchanged with a quaternary ammonium compound having aryl or alkyl groups in the range of from 10 to 22 carbon atoms, and a vehicle comprising one or more long-chain hydrocarbons or volatile silicone oils. The composition is preferably in the form of an aerosol composition additionally comprising an aerosol propellant. The composition is applied to the skin, preferably by spraying, to block and absorb the allergenic oils of toxic plants such as poison ivy and the like.

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Floyds Knobs, IN, United States of America

Anthony A Schulz