Cornell University

Albert Einstein College of Medicine

Duke University

Anthony A Sauve

Tianle Yang Redanz

Vern L Schramm

Yue Yang

Yana Cen

Farheen Sultana Mohammed

Rajendra Uprety

Gareth R Tibbs

James David Warren, Jr

Rebecca L Joyce

Peter A Goldstein

Dipti N Barman

Samie R Jaffrey

Kevin Brown

Nancy C Andrews

Wenjing Xu

Farheen Sultana Yang Mohammed

Ping Xu

Tianle Yang

Farheen Sultana Mohammad

Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Substituted alkylphenols as HCN1 antagonists

Disclosed is a compound of formula (I): wherein R, R, R, and are as defined herein. Also disclosed are methods for increasing mammalian cell NADproduction and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.

Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives

The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

Nicotinoyl riboside compositions and methods of use

The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.

Beta-nicotinate ester nucleotides and processes for preparing same

The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.

Efficient synthesis of nicotinamide mononucleotide

The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound. 

&#x3b2;-nicotinate ester nucleotides and process for preparing same

Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of nicotinamide riboside to the subject. The heart failure may be associated with iron deficiency. The method may also include administering iron to the subject.

Method of treating heart failure

The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of snaking nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

The invention provides a method of preventing or treating hearing loss in a mammal in need thereof. The method involves administering to the mammal an agent that increases intracellular NAD+ in the mammal. The invention also provides a method of determining if a compound acts as a neuroprotective agent.

Growing community of inventors

New Rochelle, NY, United States of America

Anthony A Sauve