The University of Chicago

University of Virginia Patent Foundation

Anthony A Kossiakoff

Elena K Davydova

Ernst Lengyel

Lucas J Bailey

Daniel A Engel

Mateusz Jaskolowski

Zygmunt S Derewenda

Joseph Piccirilli

Methods and compositions are provided concerning polypeptides with modifications that increase its binding affinity for the Fab region of an antibody. Methods include using the polypeptides for isolating, detecting, purifying, measuring and quantifying Fab polypeptides. Other embodiments concern kits, compositions, and solid supports containing the polypeptides and for using the polypeptides for isolating, detecting, purifying, measuring and quantifying Fab polypeptide.

Methods and compositions involving protein G variants

This disclosure is directed to compositions and methods for utilizing the boundaries of the C-terminal domains of Nucleoprotein from Zaire Ebola virus as highly stable recombinant protein antigens to generate antibodies for diagnosis and treatment of Ebola virus infection.

Recombinant antibodies that recognize the C-terminal domains of Ebola virus nucleoprotein

Compositions and methods for delivering an agent to a cell comprising a prolactin receptor are provided. Also provided is a method of inhibiting a breast, ovarian or prostate cancer cell, where the method includes a step of contacting the cell with a complex comprising a prolactin receptor ligand linked to at least one of an RNAi-inducing agent, a polynucleotide sequence encoding a polypeptide, an miRNA, a cytotoxic moiety, a chemotherapeutic moiety, a radioactive moiety or a nanoparticle. Methods of detecting a cancer cell expressing a prolactin receptor are also provided.

Receptor-mediated delivery: compositions and methods

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Chicago, IL, United States of America

Anthony A Kossiakoff