Merck Patent Gmbh

Ansgar Wegener

Dieter Dorsch

Guenter Hoelzemann

Oliver Poeschke

Michael Busch

Christos Tsaklakidis

Kai Schiemann

Hans-Peter Buchstaller

Wolfgang Staehle

Gérard Moinet

Birgitta Leuthner

Jeyaprakashnarayanan Seenisamy

Roland Kellner

Dirk Wienke

Michel Calderini

Carl Deutsch

Brigitta Leuthner

Frank Czauderna

Daniel Kuhn

Dominique Swinnen

Horacio Comas

Compounds of the formula I in which X, Y, Q, M, Qand B have the meanings indicated in Claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Macrocycles as kinase inhibitors

Compounds of the formula I in which Rand Rhave the meanings indicated in claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Triazolo[4,5-d]pyrimidine derivatives

Compounds of the formula I in which X, Rand Rhave the meanings indicated in Claimare inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Imidazopyrimidine derivatives

Compounds of the formula I in which R, R, R, X, X, X, X, n1, n2, n3 and n4 have the meanings indicated in claim are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. 

Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors

Compounds of the formula I in which Rand Rhave the meanings indicated in Claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Compounds of the formula I in which R, X and Y have the meanings indicated in Claimare inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Substituted pyrrolo[1,2-A]pyrazin-1-ones and pyrazolo[1,5-A]pyrazin-4-ones as inhibitors of tankyrase and poly(ADP-ribose)polymerase activity

The present invention relates to the use of compounds and to methods for the qualitative and/or quantitative determination of the activity of phosphoamidases or protein phosphoamidases specific for hydrolyzing phosphoamide (P&#x2014;N) bonds N-phosphorylated basic amino acids like phospholysine, phosphoarginine and phosphohistidine.

Phosphoamidase assay

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Heusenstamm, Germany

Ansgar Wegener