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Council of Scientific and Industrial Research

Zandu Pharmaceutical Works Ltd.

Anpurna Kaul

Anamika Khajuria

Sukhdev Swami Handa

Naresh Kumar Satti

Krishan Avtar Suri

Kasturi Lal Bedi

Vikram Bhardwaj

Vishwa Nath Gupta

Om Prakash Suri

Ulhas Salunkhe

Girish G Parikh

Raman Krishnamurthy

Prabhakar Kulhar

Ajit Kumar Saxena

Om Parkash Suri

Rakesh Maurya

Ashwani Kumar

Gulam Nabi Qazi

Lila Ram Manahas

Bal Krishnan Kapahi

Sarang Bani

Usha Zutshi

The present invention relates to a process for the isolation of a novel oligospirostanoside structurally constructed as 3-0-&lsqb;&agr;-L-rhamnopyranosyl-(1&rarr;2)-&agr;-L-rhamnopyranosyl-(1&rarr;4)-0-&bgr;-D-glucopyranosyl&rsqb;-25(S)-5&bgr; spirostan-3&bgr;-ol isolated from and biologically evaluated as a potent immunomodulatory agent.

Process for the isolation of novel oligospirostanoside

The present invention relates to a novel oligospirostanoside having the structure 3-0-&lsqb;&agr;-L-rhamnopyranosyl-(1&rarr;2)-&agr;-L-rhamnopyranosyl-(1&rarr;4)-0-&bgr;-D-glucopyranosyl&rsqb;-25(S)-5&bgr;-spirostan-3&bgr;-ol isolated from and to a pharmaceutical composition containing the novel oligospirostanoside and to a method for immunomodulation using said oligospirostanoside by administering a pharmaceutically effective amount of said novel oligospirostanoside.

Oligospirostanoside, pharmaceutical composition containing novel oligospirostanoside and method for immunomodulation using said oligospirostanoside

Pharmaceutical composition and a method useful for treating immunodeficiency in animals or human beings, said composition comprising effective amount of the extract obtained from any part of plant either as such or its individual constituents singly or in composition with each other, optionally associated with pharmaceutically acceptable additives.

Pharmaceutical composition comprising extract from plant Cryptolepis buchanani for treating immunodeficiency

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Jammu, India

Anpurna Kaul