Global Life Sciences Solutions USA LLC

Ge Healthcare Bio-sciences Ab

General Electric Company

Anoop Bhargav

Haresh Digambar Patil

Praveen Paul

Sebastian John

Manoj Kumar Ramakrishna

Manish Uddhaorao Choudhary

Pradeep R Kumar

Nivedita Phadke

Jeganathan Srinivasan

Swapnil Puranik

Babu Rasool Nabi

Umesh Pai

A tray configured to be provided on a base station of a bioreactor system, said tray comprising a bottom and surrounding side walls and being configured to hold a bioreactor bag, said bottom comprising at least two bottom parts, whereof one is a middle part of the bottom, wherein at least one of the bottom parts is movable into at least a first and a second position, wherein said first position provides the bottom parts substantially flush with each other providing a substantially plane bottom of the tray and said second position provides a bottom of the tray having a recessed middle part.

Bioreactor tray

Disclosed is a cell culture system comprising a first cell culture bioreactor system () for culturing cells to a predetermined cell density or quantity, the system including a bioreactor volume (), a process controller (), process control devices () which provide inputs () for the culture volume and culture parameter measurement devices (), wherein the process controller is operable according to plural control program steps to control the process devices to provide inputs for a suitable cell culture environment in the bioreactor volume, and is further operable according to control program steps modified by feedback values from the culture parameter measurement devices, and comprises a memory () operable to record data indicative of the progress of the control program steps. Failure of the system can be rectified by moving the bioreactor volume to another similar system which has access to data indicative of any incomplete program steps which steps may have been modified by feedback from the measurement devices.

Failure recovery in cell culture bioreactors

The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (), each being able to hold media for use in a bioreactor a mixing unit () for creating a uniform mixing of media a first feeding mechanism (), arranged to feed media from the supply units () into the mixing unit (), a control unit () operatively connected to the first feeding mechanism () and the mixing unit (), said control unit () being configured to control the first feeding mechanism () to feed predetermined amounts of media from the plurality of supply units () to the mixing unit (), and further being configured to control the mixing unit () to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.

Mixing system

Disclosed is a biomanufacturing apparatus () comprising a housing () including top () and bottom () faces which allow stacking of plural housings, an access door () at a front side of the housing, a substantially enclosed bioreactor chamber () inside the housing accessible via the door, and a further substantially enclosed region () inside the housing containing electrical parts and/or electronic control components, the chamber () including: a tray () for supporting a bioreactor, a tray support () including a mechanism () for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.

Biomanufacturing apparatus

Disclosed is biomanufacturing apparatuscomprising a housingincluding topand bottomfaces which allow stacking of plural housings, an access doorat a front side of the housing, a substantially enclosed bioreactor chamberinside the housing accessible via the door, and a further substantially enclosed regioninside the housing containing electrical parts and/or electronic control components, the chamberincluding: a trayfor supporting a bioreactor, a tray supportincluding a mechanismfor rocking the tray in use; the tray support further including a load cell () to determine changes in the mass load on the tray.

Disclosed is biomanufacturing apparatuscomprising a housingincluding topand bottomfaces which allow stacking of plural housings, an access doorat a front side of the housing, a substantially enclosed bioreactor chamberinside the housing accessible via the door, and a further substantially enclosed regioninside the housing containing electrical parts and/or electronic control components, the chamberincluding: a trayfor supporting a bioreactor, a tray supportincluding a mechanismfor rocking the tray in use; at least a fluid handling portionof at least one fluid pump device; and at least one connectionfor connecting to a conduit and/or path for carrying fluids, gas and/or electricity.

The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.

Bioreactor system for cell cultivation

Automated fluid handling system comprising a controller arranged to control the operation of the fluid handling system in accordance with a predefined or user-defined operation process, the fluid handling system comprising a power source input for connection to an external power source, the fluid handling system comprising a back-up power source arranged to supply back-up power to the controller, wherein the controller is arranged to monitor the power source input and

Automated fluid handling system

Absorption monitor system comprising a light source and a light detector arranged so as to define an absorption detection light path there between, and a controller arranged to control the operation of the light source, wherein the light source comprises a Light Emitting Diode capable of emitting light in the UV range (UV-LED) and wherein the absorption monitor system does not comprise a reference light-detector and the controller is arranged to compensate for fluctuations in light output intensity from the UV-LED.

Growing community of inventors

Bengaluru, India

Anoop Bhargav