Institut National De La Recherche Agronomique

Centre National De La Recherche Scientifique

Institut Pasteur

Université Paris—sud

Anny Slama Schwok

Bogdan Tarus

Patrick Couvreur

Didier Desmaele

Felix Augusto Rey

Stéphane Duquerroy

Jean-François Eleouet

Bernard Delmas

Stephane Quideau

Christina Sizun

Helene Bertrand

The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.

Antiviral agents directed against respiratory syncytial virus

A pharmaceutical composition for treating viral infections by an influenza type A virus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein. A pharmaceutical composition for treating viral infections by an orthomyxovirus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of orthomyxoviruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein of the viruses. A compound acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and binding to the viral-RNA-binding domain on the nucleoprotein of influenza type A viruses and a method for identifying such a compound having these properties are also described.

Antiviral compositions directed against the influenza virus nucleoprotein

Growing community of inventors

St. Aubin, France

Anny Slama Schwok