Illumina Cambridge Limited

Anno Koetje

Xiaohai Liu

Antoine Francais

Elena Cressina

Angelica Mariani

Adam Culley

Embodiments of the present disclosure relate to nucleotide with acetal 3'-OH blocking groups. Also provided herein are methods of using fully functionalized nucleotides containing the 3′ acetal blocking group for sequencing applications.

Methods of sequencing using nucleotides with 3' acetal blocking group

Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal 3'-OH blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses of fully functionalized nucleotides containing the 3&#x2032; acetal blocking group for sequencing applications.

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Cambridge, United Kingdom

Anno Koetje