Leica Biosystems Nussloch Gmbh

Technische Universitat Braunschweig Carolo-wilhelmina

Annika Raatz

Hermann Ulbrich

Karl-Heinrich Westerhoff

Christian Löchte

Arne Burisch

Franz Dietrich

The invention relates to an apparatus for treating histological samples, in particular for detaching and/or isolating a histological sample that, in particular after an infiltration operation, is adhering to another sample and/or to the inside of a cassette (), having a sample receiving chamber () which is embodied and intended to be filled at least partly with a liquid (), in particular with liquid paraffin. The apparatus according to the present invention is characterized in that a displacement means () is provided that is introducible into the liquid (), in particular under open- and/or closed-loop control, in order to elevate the fill level height () of the liquid (), and/or that a displacement means () is provided whose volume is increasable, in particular under open- and/or closed-loop control, in order to elevate the fill level height.

Method and apparatus for detaching and/or isolating a histological sample

The invention provides a method for detaching and/or isolating a histological sample that is adhering to another sample and/or to the inside of a cassette, for example as a result of solidification of an embedding medium within a cassette. The sample is immobilized in a sample receiving chamber above a first fill level of a liquid that is suitable for counteracting the adhesion; and that the fill level of the liquid is then elevated at least until said level reaches the sample. An apparatus according to the present invention that can be used for carrying out the method comprises a sample receiving chamber and an adjusting chamber, the adjusting chamber being connected to the sample receiving chamber in such a way that a change in the fill level height of the liquid in the sample receiving chamber is producible by changing the pressure existing in the adjusting chamber.

The invention relates to a method for execution upon processing of at least one histological sample that is arranged, in particular after an infiltration process, in a closed cassette (). The method is characterized in that prior to opening of the cassette (), the sample is detached from the cover of the cassette () and/or isolated.

Method for execution upon processing of at least one histological sample

The invention relates to a tissue sample handling apparatus, in particular for grasping histological samples after infiltration of an embedding medium such as, for example, paraffin, which is characterized in that a sample is immobilizable on the handling apparatus, in particular in a sample holding position, by means of negative pressure.

Tissue sample handling apparatus

The invention relates to an apparatus for treating histological samples, in particular for detaching and/or isolating a histological sample that, in particular after an infiltration operation, is adhering to another sample and/or to the inside of a cassette (), having a sample receiving chamber () which is embodied and intended to be filled at least partly with a liquid (), in particular with liquid paraffin. The apparatus according to the present invention is characterized in that an apparatus is provided that is introducible into the liquid (), in particular under open- and/or closed-loop control, in order to elevate the fill level height () of the liquid (), and/or that an apparatus is provided whose volume is increasable, in particular under open- and/or closed-loop control, in order to elevate the fill level height.

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Braunschweig, Germany

Annika Raatz