Astrazeneca Ab

Annika Björe

Gert Strandlund

David Cladingboel

Peder Svensson

Kurt-Jürgen Hoffmann

Magnus Björsne

Johan Kajanus

Michael Wilsterman

Christina Olsson

Adam Herring

Ulrik Gran

John Pavey

Colin Thomson

Fritiof Pontén

Karin Lövqvist

Carl-Gustav Sigfridsson

Peter Gustaf Bonn

Lal Cheema

Robert Lundqvist

Gareth Ensor

Fritiof Pontėn

Fritiof Ponten

Neil Barnwell

Peter Bonn

There is provided compounds of formula I, wherein R, R, R, Rto R, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Oxabispidine compounds for the treatment of cardiac arrhythmias

There is provided compounds of formula I, wherein R, R, R, R, Rto R, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Oxabispidine compounds useful in the treatment of cardiac arrhythmias

There is provided compounds of formula (I), wherein R, R, R, R, Rto R, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias. 

Oxabispidine compounds and their use in the treatment of cardiac arrhythmias

There is provided compounds of formula I, wherein R, R, R, Rto R, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular a trial and ventricular arrhythmias. 

There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl) -9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2 -{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arhythmias.

3,7-Diazabicyclo [3.3.1] formulations as anti-arrhythmic compounds

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Mölndal, Sweden

Annika Björe