Centre National De La Recherche Scientifique

Elro Pharma Sarl

Elro Pharma

Immupharma France

Annie Lang

Gilles Guichard

Ara G Hovanessian

Robert H Zimmer

Jose P Courty

José Courty

Jean Paul Briand

Robert Zimmer

Chantal Devin

Haixang Zhang

Ara Hovanessian

Haixing Zhang

Haixiang Zhang

Jose Courty

The present invention relates to new optically pure compounds displaying an improved anticancer activity compared to previously known complex mixtures of stereoisomers thereof. Such compounds are of formula (I): wherein each X independently represents any amino acid; n is 0 or 1; m is an integer between 0 and 3; k is an integer of at least 3; Psi is a reduced bond of formula replacing the peptide amide bond between Lys and Pro; and wherein Lys residues in pseudopeptide units of said compound of formula (I) are either all in L configuration or all in D configuration. A method for preparing such compounds, and therapeutic uses thereof are also provided. The synthetic method involves the selective reduction of the peptide bond between Lys and Pro in a dipeptide intermediate with borane. The therapeutic uses are against cancer, inflammation and for wound healing.

Optically pure compounds for improved therapeutic efficiency

Growing community of inventors

Wahlenheim, France

Annie Lang