I.d.m. Immuno-designed Molecules

Establishment Public Dit Centre National De La Recherche Scientifique

Annie-Claude Roche

Michel Monsigny

Roger Mayer

Nadia Sdiqui

The invention relates to compounds comprising one or several oligosides, each of said oligosides being fixed in a covalent manner on one or many molecules, matrixs or particles, specifically one, two or three, via an intermediary molecule possessing a nitrogen atom carried by a carbon in &agr; of a C&boxH;O group and one or many functional groups, specifically one, two or three, the covalent bond between said intermediary molecule and the oligoside being done by the intermediary of said nitrogen atom, and the covalent bond between said intermediary molecule and said molecule, said matrix, said particle, or said molecules, said matrixs, said particles being done by the intermediary of the said functional groups of said intermediary molecule and appropriate functional groups to the molecule(s), the matrix(ces) or the particle(s).

Derivatives of oligosides, their process of preparation and their applications

Macromolecular conjugates of muramylpeptides useful as a stimulant of the cellular immune systems have the formula (R--X).sub.m --(LAM) wherein R is an N-acetylmuramylpeptidyl group or a derivative thereof; (LAM) is a neoglycoprotein having affinity for macrophages or monocytes, consisting of a protein covalently substituted by more than five glycidic chains, each having at least five osidic units, X is a covalent bond between a functional group of the peptidic part of R and a functional group of (LAM) or X is the residue of a conventional bifunctional coupling agent capable of bonding to R and (LAM) by formation of covalent bonds; and m is a number greater than or equal to 1.

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Sandillon, France

Annie-Claude Roche