Dynamis Therapeutics, Inc.

Dynamis Pharmaceuticals, Inc.

Lankenau Institute for Medical Research

Dynamics Therapeutics, Inc.

Annette Tobia

Francis Kappler

Alice Marcy

Lisa Laury-Kleintop

Arturo Bravo Nuevo

The invention relates to a method of treating or preventing a condition in a subject, comprising administering to the subject an acceptable composition comprising meglumine or a salt thereof. The invention further relates to a method of improving a physiological function in a subject, comprising administering to the subject an acceptable composition comprising meglumine or a salt thereof.

Methods for maintaining or improved health, well-being and/or a physiological function in a subject

Method for the treatment or prophylaxis of dry eye disorders by the administration of alkylamino-polyhydroxyalkanes and compositions thereof.

Method for treating or preventing dry eye disorders using alkylamino-polyhydroxyalkanes

Methods for maintaining or improving health, well-being and/or a physiological function in a subject

The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

3-deoxyglucosone and skin

The invention relates to the discovery that 3-deoxyglucosone (3DG) and other alpha-dicarbonyl sugars associated diseases and disorders are present and produced in the skin. Further, the invention relates to the discovery that amadorase, an enzyme that mediates 3DG synthesis, is also present in the skin. Thus, the invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.

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Wyndmoor, PA, United States of America

Annette Tobia