Novartis Vaccines & Diagnostics, Gmbh

Novartis Ag

Annette Olga Walter

Paul A Renhowe

Paul Andrew Barsanti

David Duhl

Kris Mendenhall

Weibo Wang

Tinya Abrams

Yi Xia

Savithri Ramurthy

Sharadha Subramanian

Ryan N Constantine

Nathan Brammeier

Rustum Boyce

Megan C Phillips

Kay Huh

Hong Yang

Mark Knapp

Sabina Pecchi

Kenneth Walter Bair

Eric J Martin

Rama Jain

Liana Marie Lagniton

Elisa Jazan

Elizabeth J Mieuli

Anu Sharma

Kelly Wayman

Vincent P Le

Hongyan Guo

Rustum S Boyce

Michel Faure

Yia Xia

Jiong Lan

Matthew T Burger

Cynthia Shafer

Christopher McBride

Yasheen Zhou

Xiaodong Lin

Mika Lindvall

Gisele A Nishiguchi

Wooseok Han

Xiaojing Michael Wang

Tatiana Zavorotinskaya

Pablo Dominguez Garcia

Gordana Babic Atallah

Alice Rico

William Antonios-McCrea, Jr

Cornelia Bellamacina

Ann B Jefferson

Kris G Mendenhull

Xia Yia

Liana Marie Lagnition

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

PIM kinase inhibitors and methods of their use

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: 

Substituted imidazole derivates

The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.

Kinesin inhibitors as cancer therapeutics

Substituted imidazole derivatives

Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof: 

Substituted pyrazole and triazole compounds as KSP inhibitors

The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula (I).

Indole and benzimidazole derivatives

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses of the compounds. The compounds of the invention have the following general formula: 

Substituted imidazole compounds as KSP inhibitors

The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: 

The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: 

Substituted 2,5-heterocyclic derivatives

Growing community of inventors

Emeryville, CA, United States of America

Annette Olga Walter