Harrow Ip, LLC

Aethlon Medical, Inc.

Immunicom, Inc.

Annette Marleau

Thomas E Ichim

Dennis Elias Saadeh

Steven Francis Josephs

Steven P Larosa

Rosalia De Necochea Campion

Michael Jacobs

Michael Matho

Charles J Fisher, Jr

Jr Charles J Fisher

The devices and methods of the present invention can be used to capture and remove COVID-19 mediating nanoparticles and/or exosomes associated with COVID-19 or similar disease from the circulatory system of patients in need thereof, including those with post-COVID-19 syndrome or similar post-disease sequelae so-called 'long haul' symptoms of COVID-19 or similar disease. The present invention benefits patients by providing lectin based extracorporeal methods for binding and physically removing SARS-C7oV-2 virions, or fragments thereof, from the circulatory system. Also provided are lectin based extracorporeal methods of binding and physically removing non-viral COVID-19 mediating nanoparticles. Also disclosed herein are devices and methods for reducing the levels of biomarkers and markers of morbidity/mortality of diseases such as COVID-19 and similar diseases, including cytokines, such as IL-6, Troponin T, and D-dimer.

Devices and methods for treating a coronavirus infection and symptoms thereof

A column is disclosed for removal of sTNF-R2 from a body fluid. The column has a compartment, an inlet coupled to the compartment and configured to receive the body fluid, and a substrate disposed within the compartment. A capture ligand is coupled to the substrate and has a modified sequence with an amino acid substitution in a reference sequence that includes a portion of a natural TNF sequence. The modified sequence has an affinity for the sTNF-R2 that is greater than an affinity of the reference sequence for the sTNF-R2.

Modified TNF as a capture ligand

Pharmaceutical compositions that include aqueous suspensions of a therapeutically effective quantity of a diaminopyrimidine compound (such as pyrimethamine) are provided herein. Methods for fabricating the compositions and using them are also described.

Pyrimethamine-based pharmaceutical compositions and methods for fabricating thereof

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San Diego, CA, United States of America

Annette Marleau