American Home Products Corporation

Wyeth

Annette L Banker

John H Musser

Anthony F Kreft, Iii

Dennis Michael Kubrak

Amedeo A Failli

James Albert Nelson

Uresh Shantilal Shah

James J Bicksler

John W Giberson

Arie Zask

Semiramis Ayral-Kaloustian

Scott Christian Mayer

Middleton Brawner Floyd

Hwei-Ru Tsou

Joshua Aaron Kaplan

Xiaoxiang Liu

Kristina Martha Kutterer

Gary Harold Birnberg

Zhilian Tang

Ramaswamy Nilakantan

Tritin Tran

Marvin Reich

Mercy Adufa Otteng

This invention provides compounds of Formula (I), having the structure 

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There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid

There are disclosed compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl;

Quinolinylmethoxy naphthalenepropionic acid derivatives as

There are disclosed compounds of the formula

Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid

There are disclosed compounds of the formula ##STR1## wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, ##STR2## with the proviso that A is not quinolinyl; W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O--;

Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic

There are disclosed compounds of the formula ##STR1## wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, ##STR2## W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O-- X is N or CR;

Quinoline substituted naphthalenepropionic acid derivatives as

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Plainsboro, NJ, United States of America

Annette L Banker