0903608 B.c. Ltd.

Soligenix, Inc.

Inimex Pharmaceuticals Inc.

Annett Rozek

Karan Manhas

Oreola Donini

Michael J Abrams

Shannon Wayne Lentz

Jackson Lee

John North

Robert James Etsu Takeuchi

Sasha Ozeroff

Nathan Woodbury

Shannon Lentz

Eric Van Fleet

Jay K Shah

Devices and methods for the control of pests using the vapors of a pesticidal composition. Compostions, devices and methods for the selective control of pests while not harming one or more beneficial insects are also disclosed. In some embodiments, the pests are bed bugs, fleas, lice, ticks, or the like. In some embodiments, the pests are varroa mites and the beneficial insects are honey bees.

Compositions, devices and methods for control of pests using vapor activity

Devices and methods for the control of pests, including plant pests, using the vapors of a plant health, pesticidal and/or pest control composition are disclosed. Compositions, devices and methods for the selective control of plant or other pests while not harming one or more beneficial insects are also disclosed. In some embodiments, the pests are include bugs, fleas, lice, ticks, plant pathogenic insects, acari, or the like. In some embodiments, the pests are varroa mites and the beneficial insects are honey bees.

Compositions, devices and methods for plant health and pest control using vapor activity

Compositions and methods for increasing the efficacy of pesticidal compositions containing nicotinic acetylcholine receptor disrupters or allosteric modulators and C6-C10 saturated or unsaturated aliphatic acids are described herein, including synergistic pesticidal compositions and methods for delivery of pesticidal active ingredients. Some pesticidal compositions and methods as described are directed to compositions and methods for increasing the efficacy of fungicides. Some pesticidal compositions and methods as described are directed to compositions and methods for increasing the efficacy of nematicides. Some pesticidal compositions and methods as described are directed to compositions and methods for increasing the efficacy of insecticides. Methods for enhancing the activity pesticidal active ingredients in pesticidal compositions in use are also described.

Synergistic pesticidal compositions and methods for delivery of insecticidal active ingredients

Preclinical data obtained in models of chemotherapy-induced mucositis, radiation-induced mucositis, neutropenic infection and colitis indicate oral mucositis is a promising indication for Innate Defense Regulator (IDR) peptides. Preclinical efficacy results obtained with IDRs in mouse and hamster models of mucositis indicate that dosing every third day should be able to cover the mucositis 'window' with seven to fourteen doses, depending on the duration of chemotherapy or radiation exposure. IDRs have also shown efficacy in mouse models of chemotherapy-induced oral and gastrointestinal mucositis, consistent with the response of the innate immune response to chemotherapy and/or radiation damage. IDRs are also effective at reducing bacterial burden and improve survival in the presence or absence of antibiotic treatment in various murine infection models.

Peptides and analogs for use in the treatment of oral mucositis

Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent or an alkyl alcohol solvent. Methods of making and using the compositions are disclosed.

Pest control formulations and methods of making and using same

Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent. Methods of making and using the compositions are disclosed.

In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.

Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity

In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject, and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with this peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.

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Port Moody, Canada

Annett Rozek