Merck + Co., Inc.

Anne W Dombrowski

Sheo B Singh

Deborah L Zink

Gerald F Bills

John G Ondeyka

Dan A Ostlind

Jon David Polishook

Joyce A Greene

Otto D Hensens

Jon D Polishook

Fernando Pelaez

Michael A Goetz

Sandra J Rattray

Daria Hazuda

Lawrence R Koupal

Kevin M Byrne

Gregory L Helms

Daria Jean Hazuda

Richard G Endris

Gary K Darland

Diane M Vesey

Arlene M Dahl

Christine Lange Cannova

Janet C Onishi

Robert E Schwartz

Seok H Lee

Dennis M Schmatz

Russell B Lingham

Leeyuan Huang

Keith C Silverman

John R Thompson

Maria T Diez

Guy H Harris

James E Curotto

Hans E Huber

Wendy S Horn

Ana M Teran

Myra B Kurtz

Maria S Meinz

Stanley L Streicher

Hiranthi Jayasuriya

Richard K Jansson

Rosalind G Jenkins

Wendy H Clapp

Denis R Patrick

Mark Rattray

Ziqiang Guan

Marie Williams

Sarah J Driekorn

Jeffrey C Hastings

M Dolores Vilella Amils

Marina Mojena Sanchez

Annie Z Zhao

Peter J Felock

Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.

HIV integrase inhibitors

Disclosed is a method for controlling phytopathogenic fungi using pure strains of ATCC 74386 and fungus ATCC 74387. Further, methods of producing a sordarin compound are disclosed. The method includes cultivating each strain separately in a nutrient medium containing assimilable sources of carbon and nitrogen and recovering the compound. A sordarin compound of formula I is also disclosed. Also an antifungal composition containing a sordarin compound is also disclosed.

Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control

Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.

A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf. Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.

Bis-aryl ethers, compositions containing such compounds and methods of

Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.

Antiparasitic agents

The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.

Antiprotozoal cyclic tetrapeptides

Natural products such as equisetin and derivatives are described. These compounds are useful in the inhibition of HIV integrase.

In vitro HIV integrase inhibitors

There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.

There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.

Antifungal agents

This invention relates to processes employing cultures which are useful for preparing compounds of structural formula (I). ##STR1##

Processes for preparing cholesterol lowering compounds

This invention relates to cultures and processes employing these cultures which are useful for preparing compounds of structural formula (I). ##STR1##

Culture of Asperigillus versicolor and mutants thereof

Growing community of inventors

East Brunswick, NJ, United States of America

Anne W Dombrowski