Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Université Paris Est Creteil Val De Marne

Institut National De La Sante Et De La Recherche Medicale (inserm)

Université Technologie De Compiègne-utc

Central National De La Recherce Scientifique (cnrs)

Universite Technologie De Compiegne

Université De Technologie De Compiègne

Anne-Virginie Salsac

Eric Leclerc

Jean-Paul Couetil

Dominique Barthes-Biesel

Adrien Laperrousaz

Eric Bergoend

Thi Xuan Chu

Jean-Paul COUËTIL

Eric BERGÖEND

Implant () for a heart valve comprising two leaflets, particularly a mitral valve (MV), the implant () comprising: a clamp () comprising a body () and a jaw () rotationally hinged with the body () to pivot between an open position and a closed position in which the body () and the jaw () are able to clamp a first leaflet among the heart valve leaflets, so as to attach the implant () onto the first leaflet, a movement device () comprising a pusher element (), the movement device being configured to move the jaw () relative to the body () from the open position to the closed position or vice versa, when the pusher element () is pushed by a rod (), and a balloon () attached to the clamp () and configured to close at least partially an open portion (O) remaining between the heart valve (MV) leaflets during systole, when the implant () is attached to the first leaflet, so as to limit a reflux of blood through said open portion (O) remaining during systole.

Heart valve implant

The present invention relates to a method for producing microcapsules having a calibrated diameter and at least one parameter characteristic of the mechanical properties of an equally calibrated microcapsule, characterized in that the method includes the steps of: producing microcapsules by means of injection into a microsystem () of three fluids (f, f, f); deforming the microcapsules by means generating a flow within a capillary tube (); observing and acquiring the outline of at least one deformed microcapsule observed by an optical acquisition means (); comparing the acquired outline with outlines from a collection of reference microcapsule outlines; determining the diameter and said at least one parameter characteristic of the mechanical properties of the observed microcapsule; and modifying the flow rates (Q, Q, and/or Q) of the fluids (f, f, f). The present invention also relates to a system for producing calibrated microcapsules.

Method and system for producing calibrated microcapsules

Growing community of inventors

Choisy-au-Bac, France

Anne-Virginie Salsac