Vanderbilt University

Anne Talley

Scott A Guelcher

Katarzyna Jadwiga Zienkiewicz

Jerald E Dumas

Edna Margarita Prieto

Andrew Harmata

Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.

Growing community of inventors

Nashville, TN, United States of America

Anne Talley