Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Anne T Joergensen

Matthias Grauert

Alexander Pautsch

Steffen Breitfelder

Trixi Brandl

Udo Maier

Christoph Hoenke

Matthias Hoffmann

Stefan Scheuerer

Michael Paul Pieper

Ingo Pragst

Klaus Erb

Riccardo Giovannini

Stefan Peters

Sara Frattini

Enzo Cereda

Frank Buettner

Eckhart Bauer

Matthias Hoffman

Monica Quai

Frank Kalkbrenner

Gerhard Schaenze

New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney. 

Pteridinone derivatives as PI3-kinases inhibitors

The present invention relates to compounds of general formula (I), wherein the groups A, R, R, Rand Rhave the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.

Thiazolyl-dihydro-quinazolines

Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups Rto Rhave the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.

Thiazolyl-dihydro-quinazoline compounds and processes for preparing same

New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.

Inhibitors of PI3-kinases

Thiazolyl-dihydro-quinazoline

Disclosed are compounds of general formula (I), wherein the groups R, R, Rand Rhave the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.

Thiazolyl-dihydro-cyclopentapyrazole

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Copenhagen, Denmark

Anne T Joergensen