Centre National De La Recherche Scientifique

Other

Guangdong University of Technology

Anne Robert

Bernard Meunier

Francoise Benoit-Vical

Odile Dechy-Cabaret

Yan Liu

Daya Huang

Siwei Shu

Michel Nguyen

Xingguo Liu

Meijie Huang

Dean Wang

Weixin Zhang

Ju Huang

Liu Xingguo

A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.

Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease

The invention relates to dual molecules formed from coupling products complying with the formula 

Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof

The invention relates to dual molecules formed from coupling products complying with the formulawherein Application as medicinal products with anti-malarial activity.

Growing community of inventors

Toulouse, France

Anne Robert