Schering Corporation

Anne O'Garra

Rene De Waal Malefyt

Albert Zlotnik

Maureen C Howard

Di-Hwei Hsu

Hergen Spits

Hiroshi Ishida

Franck J Barrat

Pieter Andre Boonstra

Huub Savelkoul

Rene De Malefyt

Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.

Regulatory T cells; methods

A method is provided for toting a B cell mediated autoimmune disorder comprising administering an effective amount of an interleukin-10 antagonist.

Use of an interleukin-10 antagonist to treat a B cell mediated

A method is provided for reducing an inflammatory response in a mammal comprising administering to a mammal at risk of developing or afflicted with an inflammatory response characterized by substantially elevated levels of IL-1.alpha., IL-1.beta., IL-6, IL-8 and TNF.alpha., an amount of IL-10 effective to substantially lower the levels of such cytokines.

Use of interleukin-10 analogs for antagonists to treat endotoxin- or

A method is provided for treating septic shock or toxic shock that comprises administering an effective amount of interleukin-10.

Use of interleukin-10 (IL-10) to treat endotoxin- or

Growing community of inventors

Palo Alto, CA, United States of America

Anne O'Garra