Allelix Biopharmaceuticals Inc.

Nps Allelix Corporation

Astrazeneca Ab

Anne O'Brien

Abdelmalik Slassi

Louise G Edwards

Tao Xin

Ashok Tehim

Methvin Benjamin Isaac

Jalaj Arora

David Wensbo

Tomislav Stefanac

Donald A McLeod

Alexander Minidis

Martin Johansson

Karin Staaf

Methvin Issac

The present invention relates to new compounds of formula I, wherein P, Q, X, X, X, X, R, R, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.

Tetrazole compounds and their use as metabotropic glutamate receptor antagonists

Use of N-alkylamino-heterocylic compounds for the treatment of migraine

The present invention is directed to compounds useful in the treatment of migraine which have the general formula (II).

N-alkylamino-indoles for the treatment of migraine

Described herein are compounds with affinity for the 5-HT.sub.6 receptor, which have the general formula: wherein:

Piperidine-indole compounds having 5-HT.sub.6 affinity

Described herein are compounds with affinity for the 5-HT.sub.6 receptor, which have the general formula: ##STR1## wherein: R.sup.1 is selected from the group consisting of H and C.sub.1-4 alkyl;

Pyrrolidine-indole compounds having 5-HT.sub.6 affinity

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Toronto, Canada

Anne O'Brien