Cerus Corporation

Onyx Pharmaceuticals, Inc.

Anne North

Naheed Mufti

Anna Erickson

Gideon Bollag

Anne M Crompton

Sanju Sharma

William Roscoe

The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.

Systems and methods for testing and screening using compound bound substrates

The present invention provides pathogen-inactivated red blood cell compositions.

Pathogen-inactivated red blood cell compositions

The present invention provides pathogen-inactivated red blood cell compositions suitable for infusion into a subject.

The present invention provides improved methods for treating red blood cell compositions with a pathogen-inactivating compound under conditions which provide suitable pathogen inactivation while maintaining cell vitality. Also provided methods of reducing dehydration in red blood cells, as well as treated red blood cell compositions.

Quenching methods for red blood cell pathogen inactivation

Methods and compositions are described that affect the GTPase activity of members of the Ras superfamily, preferably Rac, such compositions include guanine nucleotide exchange factors that modulate the GTPase activity, preferably in the presence of GEF enhancers, exemplary guanine nucleotide exchange factors being Rac-GEF and Tiam-1, which are encoded by certain nucleic acid sequences that are herein described, along with uses for the guanine nucleotide exchange factors and the nucleic acid sequences including screening for ligands which recognize Rac-GEF, regulators of Rac-GEF activity, and methods of treating pathological conditions associated or related to a Ras superfamily GTPase, including Rac.

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Pleasant Hill, CA, United States of America

Anne North