Bristol-myers Squibb Compnay

Dibra S.p.a.

Anne Marie Smith

Julius P Zodda

Christoph De Haen

Michael N Eakins

Munir N Nassar

Angelo Gallotti

Michael Cucolo

A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.

Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol

Devices, and a method for the use thereof, for the standardization of signal intensity in the formation of magnetic resonance images of the human body, said devices including one or more straight, bent or flexible closed tubes with an external diameter not greater than 3 cm, an internal diameter of not less than 0.2 cm and a length of not less than 8 cm, made of susbtantially diamagnetic material, other than glass, preferably a plastic material, particularly polyvinyl chloride, each of them being filled with aqueous solutions or gels containing paramagnetic components, said tubes being kept close to the body either by means of the positioning devices of the body to which they are fixed permanently or temporarily, or by fixings which, on one side, can be fixed to the human body and on the other keep the tubes in the required positior.

Device for the standardization of signal intensity in the magnetic

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Glen Gardner, NJ, United States of America

Anne Marie Smith