Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Other

Université Paris Didrerot—paris 7

L'assistance Publique--hospitaux De Paris

Anne Marie Joutel

Elisabeth Andree Tournier-Lasserve

Marie-Germaine Madeleine Bousser

Jean-François Bach

Søren Christensen

Thorleif Jan Pedersen

Jean-Fran&ccedil;ois Bach

The present invention relates to an anti-Notch 3 antibody therapy useful for treatment of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In particular, the invention relates to an anti-Notch3 antibody or a fragment thereof having a 2 fold, 4 fold or 10 fold higher affinity to Notch 3 than to Notch 1 or Notch 2 for use in therapy.

Immunological treatment of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL and related diseases.

Gene involved in CADASIL, method of diagnosis and therapeutic application

The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL. The invention also concerns models and products for treating CADASIL and related diseases.

Gene involved in cadasil, method of diagnosis and therapeutic application

Method for screening for familial hemiplegic migraine which comprises searching for the presence of a mutated gene responsible for familial hemiplegic migraine on the chromosome 19, in the region comprised between the microsatellites D19S216 and D19S215, of a family or of an at risk individual, including fetus.

Method for the screening of familial hemiplegic migraine (FHM)

Genotypic diagnosis of CADASIL for symptomatic or at risk individuals or fetuses belonging to a family suspected of being affected by CADASIL is carried out by detecting DNA polymorphisms genetically linked to the mutated gene responsible for CADASIL, these DNA polymorphisms being located in the genetic interval of the chromosome 19 flanked by the microsatellites D198221 and D19S215 and including these microsatellites.

Growing community of inventors

Paris, France

Anne Marie Joutel