Boehringer Ingelheim (Canada) Ltd.

Boehringer Ingelheim International Gmbh

Other

Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Gmbh

Anne-Marie Faucher

Youla S Tsantrizos

Teddy Halmos

Jean Rancourt

Montse Llinas-Brunet

Nathalie Goudreau

Murray D Bailey

Dale R Cameron

Elise Ghiro

Dominik M Wernic

Bruno Simoneau

Marc-Andre Poupart

Bounkham Thavonekham

Christiane Yoakim

Karl D Hargrave

Christine A Grygon

Jeffrey O'Meara

Serge R Landry

Sebastien Morin

Patrick Deroy

James J Crute

Alexandre Gagnon

Martin Duplessis

Clint A James

Claudio F Sturino

Marc-André Poupart

Paul John Edwards

Peter White

Eric Malenfant

Jean-Eric Lacoste

Louis Morency

Martin Tremblay

Joannie Minville

Marc-Andr&eacute; Poupart

Dale Cameron

Ellse Ghiro

J James Crute

Claudio Sturino

Paul J Edwards

Jeffrey O'MEARA

Compounds of formula (I): wherein R, R, A, A, A, A, X and Y are as defined herein, are useful as inhibitors of HIV replication.

Inhibitors of HIV replication

Compounds of formula (I): wherein Ar, X, R, R, Rand Rare as defined herein. The compounds are useful as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV.

Non-nucleoside reverse transcriptase inhibitors

Racemates, diastereoisomers and optical isomers of a compound of formula (I):wherein

Hepatitis C inhibitor tri-peptides

Racemates, diastereolsomers and optical isomers of a compound of formula (I):wherein B is H, a Cor Caryl, Caralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with Calkyl; Calkoxy; Calkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with Calkyl; amido; or (lower alkyl)amide; or

Disclosed herein are compounds of formula Ar&#x2014;X&#x2014;W&#x2014;Arwherein Arand Arrepresent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)-N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.

The use of a compound of formula (II): or its enantiomers or diastereoisomers thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma virus infection, particularly human papilloma virus in a mammal, wherein R; X; X; X; R; R; W; Z; Y; T; and Rare defined herein. The present invention also provides novel compounds, pharmaceutical compositions and methods for using these compounds and compositions in the treatment or prevention of papilloma virus infection. More particularly, the present invention provides compounds, compositions and methods for inhibiting papilloma virus DNA replication by interfering with the E1-E2 protein-protein interaction essential for viral DNA replication.

Inhibitors of papilloma virus

Non nucleoside reverse transcriptase inhibitors

A racemate diastereoisomer and optical isomer of a compound of formula (I):wherein B is H, a Cor Caryl, Caralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted with Calkyl; Calkoxy; Calkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with Calkyl; amido; or (lower alkyl)amide; or

Macrocyclic peptides active against the hepatitis C virus

This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

Anti-herpesvirus compounds and methods for identifying, making and using same

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Oka, Canada

Anne-Marie Faucher