National Research Council of Canada

Anne Marcil

Yves Durocher

Traian Sulea

Danica Stanimirovic

Maria L Jaramillo

Mehdi Arbabi-Ghahroudi

Amine A Kamen

Anne E G Lenferink

Maria Moreno

Balu Chakravarthy

Colin Roger Mackenzie

Kevin Henry

Maureen D O'Connor

Marzia Martina

Umberto Banderali

Aziza Manceur

Wei Zou

Christine Gadoury

Anne Eg Lenferink

The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.

Antibodies and antibody fragments against HNAV1.7 channel and their use in pain and cancer indications

AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.

AXL-specific antibodies and uses thereof

The present invention relates to hemagglutinin-specific antibodies, fragments thereof, and uses thereof. More specifically, these antibodies and fragments thereof are able to recognize antigen from multiple influenza strains.

Hemagglutinin-specific antibodies and uses thereof

The present invention relates to isolated or purified antibodies or fragments thereof specific for Carbohydrate Anhydrase IX (CA-IX) and their use as therapeutic tools. Specifically, the present invention is directed to high-affinity Carbohydrate Anhydrase IX-specific antibodies and fragments thereof and their use as antibody-drug conjugates. Compositions for use in therapy as well as therapeutic methods are also described.

Carbonic anhydrase IX-specific antibodies and uses thereof

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Pierrefonds, Canada

Anne Marcil