Merck + Co., Inc.

Merial Limited

Anne M Gurnett

Dennis M Schmatz

Paul A Liberator

Sandra J Rattray

Georgianna S Harris

Robert Donald

Robert W Myers

Paula M Dulski

Carmen Diaz

Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.

Toxoplasma gondii cylclic GMP dependent protein kinase G as a chemotherapeutic target for antiprotozoal agents

The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated fromand. Nucleic acid molecules having sequences that encode such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potential antiprotozoal agents. As well, methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites such asand

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Cyclic GMP dependent protein kinase as a chemotherapeutic target for antiprotozoal agents

Polynucleotide encoding eimeria tenella cGMP dependent protein kinase

Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.

Histone deacetylase as target for antiprotozoal agents

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Dobbs Ferry, NY, United States of America

Anne M Gurnett