Centre National De La Recherche Scientifique

Eth Zurich

Université´ D'aix-marseille

Universite Claude Bernard – Lyon1

Bruker Biospin Gmbh

Ecole Normale Superieure De Lyon

Anne Lesage

Paul Tordo

Christophe Coperet

Olivier Ouari

Melanie Rosay

Fabien Aussenac

Gilles Casano

Alexandre Zagdoun

Aaron Rossini

Lyndon Emsley

Mélanie Rosay

Christophe COPÉRET

The present invention relates to a dinitroxide biradical compound of general formula (I): In formula (I), A is a carbon, an ammonium, or a phosphonium; each of A1 to A6 is a single bond, O, N, N(O), S, S(O), SO, C(O), or a (C1-C4) alkyl chain; and Z1 and Z2 are selected from R1 and R2 in combination, so that there is always at least one R2 group that is substituted with R3 group. In Z1 and Z2, R1 is an H, an aryl, or a heteroaryl; R2 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, or a heteroaryl; and R3 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl, an ether, an ester, or an azide. When Z1 and Z2 are combined together with the same carbon atom of the nitroxide ring to which they are bonded, they form a spirocycloalkyl or a spiroheterocycloalkyl, the spirocycloalkyl or the spiroheterocycloalkyl being substituted with R3.

Rigid dinitroxide biradical compounds used as improved polarizing agents for dynamic nuclear polarization techniques

Growing community of inventors

Rillieux-La-Pape, France

Anne Lesage