Glykos Finland Oy

Unicrop Ltd

Other

Tenboron Oy

Novartis International Pharmaceutical, Ltd.

Vtt Technical Research Centre of Finland Ltd

Helsinki University Licensing Ltd. Oy

Unicorp Ltd

Unicrop Oy

Anne Kanerva

Markku Saloheimo

Anne Huuskonen

Ann Westerholm-Parvinen

Christopher Landowski

Kimmo Koivu

Jari Natunen

Juhani Saarinen

Viktor Kuvshinov

Jukka Hiltunen

Andrei Anissimov

Anna-Liisa Hänninen

Merja Elisa Penttila

Merja Penttilä

Kari Juntunen

Noora Salovuori

Eija Pehu

Seppo Paavo Kaijalainen

Hanna Salo

Jari Helin

Filip S Ekholm

Kari Petri Juntunen

Heli Viskari

Anne Leppanen

Annamari Heiskanen

Bernhard Helk

Christian Ostermeier

Benjamin Patrick Sommer

Ramon Wahl

Anne Leppänen

Heidi Salminen

Georg Schmidt

Eero Mustalahti

Jussi Joensuu

Svetlana Kuvshinova

Merja Penttila

Anna-Liisa Hanninen

Seppo Kaijalainen

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.

Protease deficient filamentous fungal cells and methods of use thereof

Multiple proteases deficient filamentous fungal cells and methods of use thereof

The present invention relates to a conjugate comprising an anti-EGFR1 antibody or an EGFR binding fragment thereof and at least one dextran derivative, wherein the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula &#x2014;O&#x2014;(CH)&#x2014;S&#x2014;Bi2Hiiwherein n is in the range of 3 to 10; and the dextran derivative is bound to the anti-EGFR antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof.

Conjugates comprising an anti-EGFR1 antibody

Multiple protease deficient filamentous fungal cells and methods of use thereof

The present disclosure relates to compositions and methods useful for the production of recombinant glycoproteins in filamentous fungal cells, such ascells, wherein at least 90% (mol %), preferably at least 95% of the total neutral N-glycans of said produced recombinant glycoprotein are mammalian-like N-glycans. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutations that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s); ii. a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase; iii. a recombinant polynucleotide for increasing &#x3b1;1, 2 mannosidase activity;and, iv. a recombinant polynucleotide encoding said heterologous glycoprotein.

Production of glycoproteins with mammalian-like N-glycans in filamentous fungi

The present invention relates to a conjugate comprising an anti-EGFR1 antibody or an EGFR binding fragment thereof and at least one dextran derivative, wherein the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula &#x2014;O&#x2014;(CH)&#x2014;S&#x2014;BHwherein n is in the range of 3 to 10; and the dextran derivative is bound to the anti-EGFR antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof.

Described herein are compositions including filamentous fungal cells, such asfungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example,fungal cells, as the expression system.

Production of fucosylated glycoproteins

The present disclosure relates to recombinant proteins having N-acetylglucosaminyltransferase activity. The present disclosure further relates to methods for producing complex N-glycans including the steps of providing host cells containing such recombinant proteins and culturing the host cells such that the recombinant proteins are expressed.

Fusion enzymes

The present invention relates to plant biotechnology and specifically to a method for genetically transformingwith-mediated transformation system. It comprisesfor producing homologous and heterologous recombinant products including oil and protein products and assessing and screening the efficacy of plant transformation. Also disclosed are transgenicplants, seeds as well as cells, cell-lines and tissue of

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Growing community of inventors

Helsinki, Finland

Anne Kanerva