Illumina Corporation

Anne Jager

Min-Jui Richard Shen

Kathryn M Stephens

Frank J Steemers

Sasan Amini

Cydne Holt

Carey Davis

Paulina Walichiewicz

Yonmee Han

David Silva

Li Liu

Shannon Kaplan

Bala Murali Venkatesan

Sean M Ramirez

Rigo Pantoja

Justin Fullerton

Alex So

Steven Modiano

Timothy J Wilson

Neeraj Salathia

Timothy Wilson

Embodiments disclosed herein provide methods for constructing a DNA profile comprising: providing a nucleic acid sample, amplifying the nucleic acid sample with a plurality of primers that specifically hybridize to at least one target sequence comprising a SNP and at least one target sequence comprising a tandem repeat, and determining the genotypes of the at least one SNP and at least one tandem repeat in the amplification products, thereby constructing the DNA profile of the nucleic acid sample. Embodiments disclosed herein further provide a plurality of primers that specifically hybridize to at least one short target sequence and at least one long target sequence in a nucleic acid sample, wherein amplifying the nucleic acid sample using the plurality of primers in a single reaction results in a short amplification product and a long amplification product, wherein each of the plurality of primers comprises one or more tag sequences.

Methods and compositions for DNA profiling

Presented are methods and compositions for spatial detection and analysis of nucleic acids in a tissue sample. The methods can enable the characterization of transcriptomes and/or genomic variations in tissues while preserving spatial information about the tissue.

Spatial mapping of nucleic acid sequence information

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San Diego, CA, United States of America

Anne Jager