Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Institut National De La Sante Et De La Recherche Medicale

Universite Claude Bernard – Lyon1

Université Joseph Fourier

Université Lille 2 - Droit Et Santé

Anne Imberty

Isabelle Texier-Nogues

Jean-Luc Coll

Sébastien Vidal

Véronique Robert

Samy Cecioni

Susan Matthews

Karine Faure

Julie Arnaud

Benoit Guery

Aymeric Audfray

Sebastien Vidal

Multimenic lectins having a &#x3b2;-propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.

Lectins and applications for the detection of pathological state markers

The present invention relates to a calixarene-based glycosylated compound (I) having the formula: (I) wherein D is independently selected in the group comprising a &#x2014;CH-group, an oxygen atom, a sulphur atom, a sulfinyl group or a sulfonyl group, E is independently selected in the group comprising a hydrogen, an alkyl having from 1 to 10 carbon atoms, an aryl having from 6 to 20 carbon atoms, a nitrogen dioxide group, an azide group, an amino group, a guanidinium group, a halogen atom, a &#x2014;CHR group wherein R is a hydroxyl, a halogen, an amino group, a N(alkyl)group, a NH(alkyl) group, or E represents a &#x2014;CO&#x2014;R' wherein R&#x2032; is a hydrogen atom, a hydroxyl group or an amino, B represents a A-C group wherein A is independently selected in the group comprising an oxygen atom, a sulfur atom, a NH group or a (CH)group, i being an integer from 1 to 10, C is independently selected in the group comprising a hydrogen, an alkyl, an alkenyl, an alkynyl, or C is a group of formula (II). The present invention also relates to a pharmaceutical composition characterized in that it comprises the said calixarene-based glycosylated compound (I), in combination with pharmaceutically acceptable carriers or diluents. The present invention also relates to the use of the said calixarene-based glycosylated compound (I) or the said pharmaceutical composition, for the manufacture of a drug intended to prevent or treat bacterial infections from pathogens that use lectins in the first steps of infection.  

Glycomimetic compounds as anti-infectious against pathogens lectins

A fluorescent enzymatic substrate including a backbone saccharide nature having at least one saccharide unit. The saccharide unit includes a fluorophore Fand an inhibitor Iof the fluorescence of F. The fluorophore Fand the inhibitor I, either directly or by the spacer arms Band B, respectively, when at least one Band Bis present, are grafted on the same saccharide unit of the backbone saccharide. One of th groups is Fand Igrafted in the anomeric position 1 of the saccharide unit.

Saccharide fluorescent substrates, preparation method and uses thereof

Growing community of inventors

Claix, France

Anne Imberty