Asta Medica, Aktiengesellschaft

Rijksuniversiteit Groningen

Sofotec Gmbh & Co. Kg

Almirall, S.a.

Anne Haaije De Boer

Henderik Willem Frijlink

Joachim Goede

Paul Hagedoorn

Coenraad Lerk

Wolfgang Gottenauer

Andre Narodylo

Werner Sarlikiotis

Hendrikus Gerardus M Heijerman

Petrus Paulus H Le Brun

Doetie Gjaltema

A breath actuated dry powder inhaler with a single air circulation chamber for de-agglomeration of entrained powdered medicament using the energy of the inspiratory air stream. The chamber has a substantially polygonal sidewall, a plurality of air supply channels entering the chamber substantially tangentially to its sidewall. A powder channel extends through a powder dose supply region of the inhaler tangentially into the chamber. An air outlet axially extends from a discharge and connects to a discharge channel that extends to a mouthpiece. The polygonal sidewall comprises at least six straight line segments, each straight line segments being spaced at the same first distance from an adjacent one forming the plurality of air supply channels. The air supply channels have the same width. The powder channel is defined by two straight line segments which are spaced from each other at a second distance which is larger than the first distance.

Breath actuated dry powder inhaler

A breath actuated dry powder inhaler, comprising a substantially disc shaped air circulation chamber for de-agglomeration of entrained powdered medicament using the energy of the inspiratory air stream. The chamber has a substantially circular or polygonal sidewall extending about a central axis between top and bottom walls of the chamber so that the height of the chamber is smaller than its diameter. A plurality of air supply channels disposed about the circumference of the chamber, which channels extend from joint or separate air inlets and which channels enter the chamber substantially tangentially to its sidewall. At least one of the supply channels extends through a powder dose supply region of the inhaler. The chamber further comprises an air outlet axially extending from a discharge opening in the centre of the top or bottom wall of the chamber and connects to a discharge channel that extends to a mouthpiece. The inhaler comprises at least one further air circulation chamber for de-agglomeration of entrained powdered medicament, the chambers being connected to the mouthpiece in parallel.

Dry powder inhaler and method for pulmonary inhalation of dry powder

The invention relates to a powder formulation for administration by inhalation comprising an active substance and a pharmaceutically acceptable excipient, which composition has the form of a physical mixture and comprises from 5 to 25 wt. % of the excipient, and wherein the active substance has a particle size distribution of from 0.5 to 10 &#x3bc;m, and wherein the excipient has a particle size distribution of from 15 to 500 &#x3bc;m.

Powder formulation

A disperser for dry powders which can be used with different dose systems, dose weights ranging from 2 to 25 mg and different types of powder formulation. In one embodiment, the disperser acts both as a de-agglomeration (disintegration; aerosolization) means and as an air classifier for especially adhesive mixtures. Only fine drug particles are emitted whereas the larger agglomerates and carrier crystals are retained by the disperser. Another embodiment enables time controlled release of carrier crystals in these mixtures. Yet another embodiment has optimized performance with spherical pellets, containing no carrier crystals. Other possible embodiments of the invention make it possible to control the total inhaler resistance and the powder deposition in the upper respiratory tract by means of the addition of a so-called sheath flow of clean air. Modifications also enable carrier retainment in the mouthpiece and elimination of the tangential flow component of the discharge cloud.

Powder formulation disintegrating system and method for dry powder inhalers

A pharmaceutical formulation for administration by inhalation, a micronized active compound or micronized active compound mixture with a mean particle size of 0.1 &mgr;m to 10 &mgr;m being applied to a pharmaceutically acceptable excipient having a mean particle size of 200 &mgr;m to 1000 &mgr;m without the use of binders.

Particulate formulation for administration by inhalation

Pharmaceutical powder cartridge for powder inhalers for receiving a medicament depot for a large number of pharmaceutical powder doses, having an integrated metering device which comprises at least one metering cavity for receiving a predetermined quantity of a pharmaceutical powder, the integrated metering device being capable of being moved at least out of a filling position into an emptying position approximately transversely with respect to the flow direction of the pharmaceutical powder, and an inhaler for powdered medicaments, in which inhaler the medicament can be received by a patient by means of an air stream and which has a receptacle for such a pharmaceutical powder cartridge.

Inhaler for powdered medicaments

Pharmaceutical powder cartridge with integrated metering device and

A powder inhaler for medication, for example for treatment of asthma. The inhaler has a rotatable and/or displaceable active substance magazine which has several apertures for medication. The magazine is moved with the aid of a control curve mechanism by rotation and/or displacement in such a manner that a chamber prefilled with active substance mixture is always located in front of the air inlet opening. The respiratory air stream of the patient is guided through the apparatus in such a manner that the air stream empties the chamber with the active substance mixture. The active substance mixture is divided up into respirable particles in a cyclone chamber or against an impact plate and then surrounded with a jacket stream of pure air and inhaled.

Growing community of inventors

Drachten, Netherlands

Anne Haaije De Boer