Adlyfe, Inc.

Sicpa Holding Sa

Arete Associates

System of Systems Analytics, Inc.

Anne Grosset

Cindy S Orser

Eugene A Davidson

Patrick Veya

Patrick Magnin

Christophe Schaller

Olivier Lefebvre

Olivier Lefèbvre

Nicolas Trachsel

Nicolas (deceased) Trachsel

The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.

Detection of conformationally altered proteins

An ink for the engraved copperplate intaglio printing inks is disclosed, which comprises high-molecular-weight dendritic polymer as a binder component. Inks comprising such polymer can be formulated so as to contain a significantly reduced amount of organic solvent (volatile organic components, VOC) while still being in the appropriate viscosity range required by the intaglio printing process. The printed and cured intaglio ink of the present invention has improved chemical and mechanical resistance properties.

Intaglio printing ink comprising dendrimers

A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.

Misfolded protein sensor method

A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.

A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.

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La Croix-de-Rozon, Switzerland

Anne Grosset