Janssen Pharmaceutica Nv

Anne E Fitzgerald

Jing Liu

Steven P Meduna

John M Keith

Michael D Hack

Alec D Lebsack

Natalie Anne Hawryluk

Kelly J McClure

Wendy Eccles

Paul J Krawczuk

Mark D Rosen

William Moore Jones

Neelakandha S Mani

Daniel J Pippel

Steven D Goldberg

Genesis M Bacani

Alice Lee-Dutra

Zachary S Sales

James Patrick Edwards

Cheryl A Grice

Curt A Dvorak

Brock T Shireman

Brad M Savall

Heather Renee Coate

Laurent Gomez

Michael P Curtis

Terry Patrick Lebold

Frank Chavez

Aaron M Kearney

Cathy Preville

Kelly J Mcclure

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R, L and Rare as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention. 

Flap modulators

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R, L and Rare as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

FLAP modulators

The present invention relates to compounds of Formula (I), or a form thereof wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention. 

The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl; Ris H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazoyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino; Ris H, alkyl, alkoxy, hydroxyalkylene, or halo; Z is NH, N-alkyl, or O; Ris pyridyl, pyrimidinyl, pyrazinyl, pyridazyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo; and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention. 

Substituted 7-azabicycles and their use as orexin receptor modulators

Benzofuro- and benzothienopyrimidine compounds are described, which are useful as Hreceptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

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Anne E Fitzgerald