Ucb Pharma, S.a.

Ucb S.a.

Anne-Catherine Burteau

John Surtees

Emile Cavoy

Celal Ates

Violeta Marmon

Pierre Jacobs

François Collignon

Emmanuel Van Vaerenbergh

The present invention relates to an improved process for the preparation of (S)-(&#x2212;)-&#x3b1;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein Ris methyl or ethyl; and Ris C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes. 

Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues

A catalyst comprising a chiral transition metal-(1,2-bis(2,5-dialkylphospholano) complex immobilized on a specific zeolitic support useful for the hydrogenation of prochiral substrates.

Hydrogenation catalysts

The present invention relates to an improved process for the preparation of (S)-(&#x2212;)-&#x3b1;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein Ris methyl or ethyl; and Ris C?2#191&#x2013;C?4#191 alkyl, C?2#191&#x2013;C?4#191 alkenyl or C?2#191&#x2013;C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes 

Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues

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Grand-Leez, Belgium

Anne-Catherine Burteau