Becton Dickinson and Company Limited

Applied Genetics Incorporated Dermatics

Anne B Brown

Matthew P Collis

Thomas L Fort

Oscar J Llorin

Daniel B Yarosh

Dolores M Berger

David A Brown

William A Nussbaumer

Daretta A Yursis

Matthew P Collins

The invention provides T4 endonuclease V compositions that exhibit enhanced stability, including stability at non-refrigerated temperatures, through reduced activity of cryptic proteases. Methods for detecting cryptic protease activity and methods for reducing such activity are also provided.

Stabilization of T4 endonuclease V

The present invention relates to a method and composition for stabilizing clinical specimens (i.e., cells in biological samples) for transport and subsequent testing for diagnosis. The composition is specifically capable of maintaining nucleic acid in the cells intact for hybridization with oligonucleotide capture and detector probes.

Composition for providing long term stability to cells for diagnostic testing

The present invention relates to methods in which ion exchange resins are used to reduce the amount of substances which interfere with nucleic acid hybridization in samples. The methods also stabilize the samples. Kits containing the ion exchange resins render the methods convenient to use.

Sample processing method using ion exchange resin

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Ellicott City, MD, United States of America

Anne B Brown