Verily Life Sciences LLC

Amazon Technologies, Inc.

Annapurna Karicherla

Bo Lu

Huanfen Yao

Kedar G Shah

Brian Pepin

Benjamin K Yaffe

Martin Sheridan

Kimberly Kam

Shivkumar Sabesan

Miro Yakov Shverdin

Cindy Au

Ken Rys

Kassidy MacPhail

Carla Alejandra Gimenez

Ohseung Kwon

Celine Liong

Bejamin K Yaffe

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

Pill with needle delivery system having outwardly expanding mechanical actuation

Embodiments relate to an implantable device. Specifically, a device includes a flexible connection component that includes a set of conductive filaments that connect a set of electrodes (or traces connected to the electrodes) and circuitry that receives and/or transmits electronic signals from and/or to the electrodes.

Implantable medical devices with microfabricated leads

The present disclosure relates to mapping catheters, and in particular to mapping catheters having thin film electrodes used in sensing electrical activity within a patient. Particularly, aspects of the present disclosure are directed to a medical device having a hollow core, a balloon disposed over at least a portion of the hollow core, and a flexible framework having one or more thin film elements formed on at least a portion of the balloon. The one or more thin film elements comprise a plurality of mapping electrodes.

Thin film mapping catheter

Systems and methods for testing a biological sample for each of two or more target pathogens employ fluorescence detection from a single fluorescence reading chamber. A method of testing a biological sample for each of two or more target pathogens includes forming a detection cycle liquid by combining detection cycle compounds with a biological sample liquid formed from a biological sample. The detection cycle compounds include respective CRISPR enzymes for each of the two or more target pathogens. The respective CRISPR enzymes are tagged with respective spectrally unique fluorescent probes. The detection cycle liquid is exposed to a multi-wavelength fluorescence excitation light. A multi-wavelength fluorescence light emission detection signal indicative of intensity of fluorescence light emitted by the detection cycle liquid over multiple wavelengths is processed to generate detection data indicative of presence or absence of each of the two or more target pathogens in the biological sample.

System and methods for detecting pathogens using multi-wavelength sensing

The present disclosure relates to a monolithic thin-film lead assembly and methods of microfabricating a monolithic thin-film lead assembly. Particularly, aspects of the present disclosure are directed to a monolithic thin-film lead assembly that includes a cable having a proximal end, a distal end, a supporting structure that extends from the proximal end to the distal end, and a plurality of conductive traces formed on a portion of the supporting structure. The supporting structure includes one or more layers of dielectric material. The monolithic thin-film lead assembly may further include an electrode assembly formed on the supporting structure at the distal end of the cable. The electrode assembly includes one or more electrodes in electrical connection with one or more conductive traces of the plurality of conductive traces.

Monolithic lead assembly and methods of microfabricating a monolithic lead assembly

Embodiments relate to implantable-lead devices that include one or more materials with altered morphology and methods for making and using the same. Specifically, the morphology of electrodes and/or one or more other implant-device materials can be textured to include micro- and/or nanoscale topographical features, which can reduce in vivo fibrotic response and thereby improve signal-to-noise ratios and short-term extractability of the devices.

Altered material morphology for reducing fibrotic load, reducing noise and improving extractability of implantable leads

A stimulation system can include one or more stimulating components, each of which can include one or more electrodes and one or more leads. Each lead can be connected at a first end of the lead to an electrode of the one or more electrodes and can be connected at a second end of the lead to a bonding pad of the one or more bonding pads. The stimulation system can also include a cylindrical substrate. Each stimulating component can be secured to a surface of the cylindrical substrate. The stimulation system can further include a skull-mount package that includes electronics that identify stimulation parameters. The bonding pads can be electrically connected to the electronics. The skull-mount package can further include one or more bonding pads. Each lead can be directly electrically and physically connected to a bonding pad of the one or more bonding pads.

Stimulation system with monolithic-lead component connected to skull mount package

Thin film connectors are described for connecting a lead assembly and a data acquisition system. Particularly, a connector includes a button having a housing and conductive pins extending from a proximal end of the housing through a base plate into a cavity on a distal end of the housing. The connector further includes a thin-film adapter having: (i) a supporting structure, (ii) bond pads formed on the supporting structure, (iii) a cable having conductive traces electrically connected to the bond pads, and (iv) feedthroughs that pass through the supporting structure and are electrically connected with the bond pads. Each conductive pin extends through a feedthrough, and each conductive pin is in electrical connection with one or more conductive traces via each bond pad.

Thin-film connectors for data acquisition system

The present disclosure relates to data acquisition, and in particular to thin film connectors between a lead assembly and a data acquisition system. Particularly, aspects of the present disclosure are directed to a connector that includes a button having a housing and conductive pins extending from a proximal end of the housing through a base plate into a cavity on a distal end of the housing. The connector further includes a thin-film adapter having: (i) a supporting structure, (ii) bond pads formed on the supporting structure, (iii) a cable having conductive traces electrically connected to the bond pads, and (iv) feedthroughs that pass through the supporting structure and are electrically connected with the bond pads. Each conductive pin extends through a feedthrough, and each conductive pin is in electrical connection with one or more conductive traces via each bond pad.

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Cupertino, CA, United States of America

Annapurna Karicherla