Osteotech, Inc.

Annamarie B Prewett

Robert K O'Leary

Roger C Stikeleather

Simon Bogdansky

Robert K O'leary

Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.

Processing of fibrous connective tissue

Demineralized bone particles having a median length to median thickness ratio of at least about 10:1 are incorporated in an osteogenic composition useful for repairing bone defects.

Process for producing flowable osteogenic composition containing

A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.

Shaped, swollen demineralized bone and its use in bone repair

An osteogenic composition is obtained from demineralized bone tissue.

Osteogenic composition and implant containing same

Demineralized bone particles and flowable osteogenic composition

Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.

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Little Silver, NJ, United States of America

Annamarie B Prewett