Memorial Sloan Kettering Cancer Center

Annamalai Selvakumar

Richard John O'Reilly

Ekaterina Doubrovina

Aisha Nasreen Hasan

Bo Dupont

Xiao-Rong Liu

Richard J O'reilly

Richard J O'REILLY

Provided herein are methods of generating antigen-specific T cells for therapeutic administration to a human patient having or suspected of having a pathogen or cancer, utilizing soluble IL-15/IL-15Rα complexes ex vivo, in cell culture during ex vivo sensitizing of T cells to the antigen or during ex vivo culturing of antigen-specific T cells. Also disclosed are antigen-specific T cells generated by such methods, and methods of treating a human patient using such antigen-specific T cells. Cell culture systems comprising human T cells, antigen-presenting cells, and soluble IL-15/IL-15Rα complexes are also provided.

Use of the IL-15/IL-15Rα complex in the generation of antigen-specific T cells for adoptive immunotherapy

This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.

Immunogenic WT-1 peptides and methods of use thereof

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Bronx, NY, United States of America

Annamalai Selvakumar