Mcgill University

Universita′ Degli Studi Di Milano

Università Degli Studi Di Parma

Universita Degli Studi Di Urbino

Fraschini, Franco

Gobbi, Gabriella

Annalida Bedini

Giorgio Tarzia

Marco Mor

Franco Fraschini

Gilberto Spadoni

Gabriella Gobbi

Silvia Rivara

Valeria Lucini

Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C-Calkyl, C-Ccycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, &#x2014;OCF, CF, C-Calkyl, C-Calkyloxy, C-Calkylthio, halogen and &#x2014;Z&#x2014;(CH)-A; Ris selected from the group consisting of C-Calkyl, C-Ccycloalkyl, CF, hydroxy-substituted C-Calkyl, hydroxy-substituted C-Ccycloalkyl, and NHR, wherein Ris C-Calkyl or C-Ccycloalkyl; Ris selected from the group consisting of: hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; R and Rmay be connected together to form an &#x2014;O&#x2014;(CH)bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris selected from the group consisting of hydrogen and C-Calkyl; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; and Ris selected from the group consisting of hydrogen and C-Calkyl.

Melatonin ligands having antidepressant activity as well as sleep inducing properties

Growing community of inventors

Urbino, Italy

Annalida Bedini