Centre National De La Recherche Scientifique

Université Louis Pasteur

Annabelle Bertin

Delphine Felder-Flesch

Jérôme Steibel

The invention relates to dendritic chelated compounds, to methods for producing the same and to pharmaceutical compositions containing the same. The dendritic chelated complexes of the present invention have the following formula (I): [[MC]E-[D]-XXXX]zB(I), where m is a magnetic or scintigraphic marker, C is a chelating agent of the marker M, E is a spacer, n=0 or 1, D is compound capable of forming a dendritic structure, m is an integer equal to 1 or 2 or 4, Xis a group increasing the complex lipophily, p1 is an integer from 0 to 12, Xis a group increasing the complex specificity for a particular organ, p2 is an integer equal to 1 or 2 or 4, Xis a group having a therapeutic activity, p3 is an integer equal to 0, 1, 2 or 4, Xis a CHgroup, p4 is an integer from 0 to 12, B is a counter-ion, z is an integer equal to 0, 1, 2, 3 or 4. The invention can be used in the field of pharmacy, more precisely in medical imaging.

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Strasbourg, France

Annabelle Bertin