Medivir Ab

Janssen Products, LP

Anna Winqvist

David Bernard Smith

Joseph Armstrong Martin

Nils-Gunnar Johansson

Genaidy Kalyanov

Genadiy Kalyanov

Pierre Jean-Marie Bernard Raboisson

Tim Hugo Maria Jonckers

Koen Vandyck

Karl Magnus Nilsson

Horst Wahling

Genadiy Kalayanov

Michael Pelcman

Bengt Christian Sund

Pedro Manuel Passos Pinho

Horst Jürgen WÄHLING

Compounds of formula I: including any possible stereoisomers thereof, wherein:

Phosphoramidate derivatives of nucleosides

4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

Antiviral nucleosides

4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

Growing community of inventors

Huddinge, Sweden

Anna Winqvist