The University of New Mexico

Health Research, Inc.

Anna Waller

Larry A Sklar

Eric R Prossnitz

Peter C Simons

Daniel F Cimino

Oleg Ursu

Sean Biggs

William C Burhans

Catherine E Prudom Gineste

Christopher P Allen

Provided are methods and compositions for reducing superoxide anions such that a prophylactic or therapeutic effect against conditions associated with excess oxidative stress achieved. The compositions and methods provide for reducing inflammation and for enhancing lifespan of eukaryotic organisms. A screen for identifying compounds that can be used in these methods is also provided.

Methods for reducing superoxide anions in eukaryotic organisms

The present invention relates generally to molecular assemblies, more particularly to an assay for the detection of G-protein coupled receptor (GPCR) molecular assemblies and bead-based detection of ligand-GPCR complexes and to methods for identifying compounds as agonists, partial agonists or antagonists of the binding of G-protein coupled receptors to G-protein and for use of these compounds in the treatment of conditions or disease states in a mammalian subject or patient, including humans, where G-protein coupled receptor binding to G-protein is implicated.

Multiplex analysis for high throughput discrimination of GPCR agonists and antagonists

Growing community of inventors

Albuquerque, NM, United States of America

Anna Waller